Molecular taxonomy of hypothalamic cell types 

Campbell JN, Macosko EZ, Fenselau H, Pers TH, Lyubetskaya A, Tenen D, Goldman M, Verstegen AM, Resch JM, McCarroll SA, Rosen ED, Lowell BB, Tsai LT. A molecular census of arcuate hypothalamus and median eminence cell types. Nat Neurosci. 2017 Mar;20(3):484-496. PMCID: PMC5323293.

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Gene regulatory networks governing insulin resistance in adipocytes

Tsai L*, Kang S*, Zhou Y, Evertts A, Xu S , Griffin M, Issner R, Whitton H, Garcia B, Epstein C, Mikkelsen T, Rosen E. Identification of nuclear hormone receptor pathways causing insulin resistance by transcriptional and epigenomic analysis. Nature Cell Biology. 2015 Jan;17(1):44-56. PMCID: PMC4281178. (* Both authors contributed equally to this work)

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Kang S, Tsai LT, Rosen ED. Nuclear Mechanisms of Insulin Resistance. Trends Cell Biol. Trends Cell Biol. 2016 May;26(5):341-51. PMCID 4844850.

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Characterizing the adipocyte epigenome

Roh HC, Tsai LTY, Shao M, Tenen D, Shen Y, Kumari M, Lyubetskaya A, Jacobs C, Dawes B, Gupta RK, Rosen ED. Warming Induces Significant Reprogramming of Beige, but Not Brown, Adipocyte Cellular Identity. Cell Metab. 2018 May 1;27(5):1121-1137. PMCID: PMC5932137.

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Roh HC, Tsai LT, Lyubetskaya A, Tenen D, Kumari M, Rosen ED Simultaneous transcriptional and epigenomic profiling from specific cell types within heterogeneous tissues in vivo. Cell Reports. 2017 Jan 24;18(4):1048-1061. PMCID: PMC5291126.

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Roadmap Epigenomics Consortium*, Kundaje A, et al. Integrative analysis of 111 reference human epigenomes. Nature. 2015. Feb 19;518(7539):317-30. PMCID: PMC4530010.

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Long JZ, Svensson KJ, Tsai L, Zeng X, Roh HC, Kong X, Rao RR, Lou J, Lokurkar I, Baur W, Castellot JJ Jr, Rosen ED, Spiegelman BM. A smooth muscle-like origin for beige adipocytes. Cell Metabolism. 2014 May 6;19(5):810-20. PMCID: PMC4052772

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Ziller MJ, Gu H, Müller F, Donaghey J, Tsai LT, Kohlbacher O, De Jager PL, Rosen ED, Bennett DA, Bernstein BE, Gnirke A, Meissner A. Charting a dynamic DNA methylation landscape of the human genome. Nature. 2013 Aug 22;500(7463):477-81. PMCID: PMC3821869

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